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Keywords: acute kidney injury, bibliometric analysis, chronic kidney disease, hydrogen-rich saline, hydrogen-rich water, inflammation, nephrotoxicity, PRISMA, renal protection, Scopus database, Web of Science database Introduction Scientific and medical interest in molecular hydrogen (H₂) dates back to the 1970s, when its potential as an antitumor agent was first explored under hyperbaric conditions.1 Initially, research primarily focused on cancer therapy, and broader medical implications remained relatively unexplored until 2007, when H₂ was recognized as a selective antioxidant capable of neutralizing highly reactive hydroxyl radicals and peroxynitrite, without disturbing essential cellular signaling molecules.2 This key discovery, originally demonstrated in cerebral ischemia-reperfusion (I/R) injury models, provided the foundation for exploring H₂-based therapies targeting diseases associated with oxidative stress and inflammation
